Help! What enzyme is at work with a drug called "orlistat"and how does it work?
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- None. Orlistat PREVENTS the body from using the enzyme pancreatic lipase, resulting in the inability of the digestive system to turn triglycerides into absorbable free fatty acids. Triglycerides are the main component in vegetable and animal fats. When taking this medication, the fats you ingest are excreted rather than digested. At the standard prescription dose of 120 mg three times daily before meals, orlistat prevents approximately 30% of dietary fat from being absorbed,[6] and about 25% at the standard over-the-counter dose of 60 mg. The primary side effects of the drug are gastrointestinal-related, and include steatorrhea—that is, oily, loose stools; because orlistat blocks some of the dietary fat from being absorbed, the fat is excreted unchanged in the feces—, fecal incontinence, frequent or urgent bowel movements, and flatulence. For more information please read http://en.wikipedia.org/wiki/Orlistat Hope this helps!
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